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Promoter Methylation Status and Protein Expression of BRCA2 in Patients with Epithelial Ovarian Cancer
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نویسنده
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Shabanizadeh Ahmad ,Dahim Hajar ,Salahshoor Reza ,Taghipour Zahra ,Taghavi Mohammad Mohsen ,Gafarineveh Hamidreza ,Eslami Bahram ,Babazadeh Zahra ,Fatehi Farangis
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منبع
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middle east journal of cancer - 2013 - دوره : 4 - شماره : 1 - صفحه:15 -20
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چکیده
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Background: ovarian cancer is the leading cause of death among gynecological cancers. changes in the methylation of brca1 and brca2 may be an effective mechanism for breast and ovarian cancer. this study evaluates the protein expression and methylation status of brca2 in iranian patients. methods: we assessed 60 mullerian-type ovarian cancers by methylation-specific pcr assays and immunohistochemistry. results: according to methylation status analysis, there were 7 of 60 (11.66%) methylated cases that had low protein expression. conclusion: we concluded that changes in the methylation status of brca2 cannot be used as an appropriate biomarker to ascertain the development of ovarian cancer.
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کلیدواژه
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Ovarian cancer ,Tumor suppressor ,Methylation
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آدرس
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rafsanjan university of medical sciences, Faculty of Medicine, Department of Anatomy, ایران, Shahid Beheshti Hospital, Department of Pathology, ایران, kermanshah university of medical sciences, Faculty of Medicine, Department of Anatomy, ایران, rafsanjan university of medical sciences, School of Medical Sciences, Department of Anatomy, ایران, rafsanjan university of medical sciences, School of Medicine, Department of Anatomy, ایران, rafsanjan university of medical sciences, Faculty of Medicine, Department of Anatomy, ایران, Kashmar University of Medical Sciences, Faculty of Nursing, Department of Anatomy, ایران, isfahan university of medical sciences, Faculty of Medicine, Department of Anatomy, ایران, rafsanjan university of medical sciences, Faculty of Medicine, Department of physiology, ایران
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Authors
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