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Nephrogenic Diabetes Insipidus: A Rare Presentation in Multiple Myeloma
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نویسنده
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Dehghani Mehdi ,Mohammad Karimi Vahid
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منبع
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middle east journal of cancer - 2012 - دوره : 3 - شماره : 2-3 - صفحه:89 -92
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چکیده
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We report a case of multiple myeloma that presented with anorexia, fatigue, high erythrocyte sedimentation rate, bone marrow plasmacytosis of more than 30%, polyuria,and low urine specific gravity. this unusual presentation was diagnosed as nephrogenic diabetes insipidus secondary to a proximal tubular dysfunction. the tubular functional disturbance appeared to be related to thepresence of lambda-type light chains. the patient was treated with desmopressine without response. after one month of treatment with thalidomide and dexamethasone for myeloma there was a dramatic response with decreased urine output.
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کلیدواژه
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Nephrogenic diabetes insipidus ,Multiple myeloma ,Lambda light chain ,Amyloidosis
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آدرس
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shiraz university of medical sciences, Hematology Research Center, ایران, shiraz university of medical sciences, Hematology Research Center, ایران
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Authors
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