Unique Variant Complex Chromosome Translocation in Myeloid Leukemia: Report of a Case and Literature Review

Background: according to the literature, there are a number of chronic and acute myeloid leukemias with unique, complex chromosome translocations. this study aims to conduct a brief review of the incidence of complex chromosome translocations in myeloid leukemia and reports a case of myeloid leukemia with complex chromosome translocations. methods: we conducted a web-based search for all peer review articles published on the subject of complex chromosome tranlsocations in chronic and acute myeloid leukemia in medline, pubmed and mitelman (http://cgapanci.nih.gov/chromosomes/mitelman) databases in addition to other pertinent web references. in addition, we performed conventional cytogenetic studies of 24- to 72-h cultures on bone marrow/peripheral blood cells obtained from the current case. cells were finally treated by the giemsa-trypsin-giemsa banding technique. results: the result of this case revealed an abnormal karyotype that had a novel complex translocation which involved chromosomes 2, 5, 9, and 22. we performed karyotyping after the initiation of chemotherapy. karyotyping results showed a complexkaryotype 46,xx,t(9;22;2;5). conclusion: this study discusses a case of chronic myeloid leukemia with complex chromosome translocations and may provide novel information regarding thesetranslocations in leukemias.