Smoking and Histological Factors Influencing Long-term Survival of Gastric Carcinoma in Consecutive Patient Series

Background: there is little information about the possible influence of lifestyleand etiologic risk factors on survival amongst patients with gastric cancer. methods: we recruited a consecutive series of 249 patients with definite diagnosisof gastric cancer who had been hospitalized in towhid hospital, sanandaj, kurdistanprovince in western iran during a five-year period from 2006 until 2011. survival ratewas calculated according to the kaplan-meier and log rank statistical methods. coxhazard regression was used to investigate the effect of the variables and adjust for theeffect of age.results: according to univariate analysis, related variables that included age,gender, residence, histology grade, histology type, familial history of gastrointestinalcancer and mental illness during the disease had no significant effects on survival ratevariation. significant independent factors on survival included past medical history ofgastrointestinal diseases (p-value = 0.010), tobacco smoking (p-value = 0.012), andearly diagnosis (p-value = 0.008). cox-regression analysis of demographic, lifestyleand histological factors with > 45 years of age as the reference revealed that patients46-65 years of age at diagnosis (hr=0.602; 95% ci=0.250-1.44; p=0.256) and those > 66 years of age (hr=1.07, 95% ci=0.46-2.50, p?0.001) had an increased risk fordisease progression and death. conclusions: past medical history of gastrointestinal diseases, tobacco smoking andearly stage diagnosis might influence the long-term survival of patients with gastriccancer.