A Rare Case of Anti-Yo Antibody Associated Paraneoplastic Sensory Polyganglionopathy in a Patient with Ovarian Cancer

Paraneoplastic cerebellar degeneration is a rare, fatal neuronal syndrome associatedwith ovarian, breast and lung cancers. anti-yo antibody mediated paraneoplasticcerebellar degeneration is known to be associated with gynecological malignancies,especially ovarian cancer. however, there are no reports of anti-yo antibody associatedpredominant peripheral mixed sensory and motor neuropathy in patients with ovariancancer. hereby, we present a case of a 75-year-old female who predominantly developedperipheral mixed sensory and motor neuropathy after undergoing surgery and adjuvantchemotherapy for figo stage 3, high grade serous ovarian carcinoma. she presentedapproximately 11 months after completion of her chemotherapy with a history ofprogressive peripheral mixed sensory and motor neuropathy that affected both upperand lower limbs. there was no evidence of recurrent ovarian cancer. since paraneoplastic peripheral neuropathy is a rare disorder, timely diagnosisand early therapeutic intervention can achieve a better outcome, although managementof paraneoplastic neurological disorders still remains a challenge for clinicians.