Clinicopathological Significance of CD105 Expression in Squamous Cell Carcinoma of the Oral Cavity

Background: angiogenesis is essential for the growth, invasion and metastasis ofsolid tumors. research on related factors such as microvessel density can be helpfulin predicting a tumor's behavior. cd105 has been introduced as a marker of angiogenesiswhich stains vessels that are in the proliferating stage. there are some controversiesabout the relation of microvessel density and clinicopathological features of oralsquamous cell carcinoma. the aim of this study is to determine the cd105 expressionin oral squamous cell carcinoma and its relation to the clinicopathological features ofthis disease.methods: we studied a total of 42 patients who had oral squamous cell carcinoma.the control group consisted of 15 cases with normal oral epithelium. cd105immunostaining was performed on 4 ?m thick tissue sections. intratumoral andperitumoral microvessel density in ten areas of the sections were recorded by twopathologists.results: there was a significantly higher cd105 microvessel density value in thetumoral tissues compared with normal tissues. in addition, there was more expressionof this marker in the invasive front area. the cd105 microvessel density value had apositive relation with lymph node metastasis. there was an association between tumorsize and cd105 microvessel density in the invasive front region. a negative associationbetween tumor grade and cd105 microvessel density value in the intratumoral regionwas observed. in both areas, cd105 expression was higher in cases with advancedclinical stage. there was no association between this marker and patients' ages or gender. conclusion: cd105 microvessel density can be a useful factor for predicting thecourse of oral squamous cell carcinoma.