Concordant Expression of Estrogen and Progesterone Receptors in Primary and Loco-regional Recurrent Breast Cancer

Background: malignant neoplastic lesions of the breast are one of the maincauses of cancer death among women. several factors can be influential in thetreatment process of breast cancer patients. the expression status of estrogenand progesterone receptors in tumor cells is among the most importantdeterminants affecting the treatment approach and prognosis of these patients.in this paper, we will evaluate changes in the expression of these biomarkersbetween primary and loco-regional recurrent tumors in breast cancer patients.methods: this cross-sectional study included 50 female patients aged 30to 85 years old who underwent surgical intervention between 1994 and 2011.all experienced loco-regional recurrence of the primary tumor between 6months and 12 years after the first therapeutic intervention. detection ofestrogen and progesterone receptors was based on the immunohistochemistrystaining of tissue samples of malignant neoplastic lesions prepared fromtissue biopsies of patients with primary or recurrent breast cancer.results: no statistically significant change in the expression of estrogenand progesterone receptors between primary tumors and their matching loco-regional were seen (p > 0.05). conclusion: this research shows no significant changes in estrogen andprogesterone receptor expression after loco-regional recurrence of tumors inbreast cancer patients. it can be concluded that the assessment of the expressionof these biomarkers in primary tumors provides reliable information for thetreatment approach of loco-regional tumors.