stromal cell-derived factor1 genetic variation at locus 801 in patients with endometrial cancer

Background: the gene’s 3′ untranslated region of stromal cell-derived factor1 (sdf-1/ cxc chemokine ligand 12 (cxcl12)) contains a polymorphism, known as sdf1-3′a at location 801, and has been linked to various types of cancers. the present study aimed to evaluate the relationship between this polymorphism and genetic predisposition to endometrial cancer.method: in this case-control study, dna was extracted from blood samples of 108 endometrial cancer patients and 123 healthy individuals through salting out method. genotyping was done by restriction fragment length polymorphism-polymerase chain reaction method, and the data were analyzed using chi-square test.results: a total number of 67 (62%) patients emerged as gg genotypes, 35 (32.4%) with ga, and 6 (5.6%) with aa genotypes. the frequency of gg, ga and aa in healthy control group was found to be 68 (55.3%), 50 (40.6%) and 5 (4.1%), respectively. furthermore, the most frequent allele in both patient (169 (78.25%)) and control (186 (75.6%)) groups was g allele. however, no significant difference was observed between genotypes and alleles frequencies between the two groups. furthermore, no significant association was observed between genotypes distribution and menopausal status (p = 0.70), tumor size (p = 0.62), degree of tumor differentiation (p = 0.74), stage (p = 0.35), tumor type (p = 0.22), and myometrial invasion (p = 0.22).conclusion: our results show that sdf1-3′a at location 801 may not enhance the risk of endometrial cancer. however, further research with a larger sample size is required to understand the molecular behavior of the sdf-1 gene polymorphism in endometrial cancer.