bmi-1 gene expression in patients with acute and chronic myeloid leukemia in the northeast of iran

Background: the b-cell-specific moloney murine leukemia virus integration site1 (bmi-1) is one of the famous members of the polycomb ring finger group, which plays a crucial role in the gene transcription regulation through histone changes. hence, it is believed to be necessary to further clarify the effects of the bmi-1 clinical. method: this cross-sectional study was conducted on 70 acute myeloid leukemia (aml), 70 chronic myeloid leukemia (cml), and 20 healthy individuals, as the control group. we used real-time quantitative polymerase chain reaction in order to assess the bmi-1 level expression and its effect on prognosis in aml patients in the molecular pathology research center. results: the results of the present work indicated that the bmi-1 overexpression was significantly higher in the aml and cml patients compared with that in the healthy controls (p < 0.001). furthermore, a significant relationship was observed between the bmi-1 overexpression and poor prognosis in the aml patients (hazard ratio=1.749, p < 0.001, 95% confidence interval = 1.31-2.32). additionally, bmi- 1high was found in chronic and blastic phase in the cml patients (p < 0.001). conclusion: we concluded that investigation of bmi-1 gene expression pattern will be conducive to the prognosis and treatment of myeloid leukemia.