expressions of yap-1, anxa10, and unc5d in tissues of papillary thyroid carcinoma; prognostic, pathological, and clinical significance

Background: there is an ongoing need for targeted therapy and systemic treatment protocols for papillary thyroid carcinoma (ptc) patients. yes activated protein-1 (yap-1) has been found to control many targets of hippo pathway. annexin family is a huge family playing many roles in cellular processes. annexin a10 (anxa10) is a member of annexin family. uncoordinated-5d (unc5d), a recently discovered unc5 family member which is found in normal tissues and downregulated in cancer cell lines and tissues. aim of the study was to assess the expression of yap-1, anxa10, and unc5d in ptc and in non-neoplastic tissues of thyroid gland using immunohistochemistry to evaluate their clinical significance and prognostic values in ptc patients.method: in the present prospective study, we took samples from 60 patients with ptc and 30 samples from non-neoplastic thyroid tissues for yap-1, anxa10, and unc5d immunohistochemistry. all the patients were followed up for assessment of the prognostic, clinical, and pathological of their expression.results: upregulation of yap-1 and anxa10 in addition to downregulation of unc5d was found in ptc tissues more than non-neoplastic thyroid tissues. in ptc tissues, there were positive associations between high yap-1 and anxa10 expression, low unc5d expression, tumor size (p = 0.022, 0.011, 0.014), presence of lymph node metastases (p = 0.005, < 0.001, 0.008), and inferior disease-free survival rate (p = 0.003, 0.01, 0.03).conclusion: upregulation of yap-1 and anxa10 expression and downregulation of unc5d was associated with bad clincopathological criteria, disease progression, high incidence of disease recurrence, and poor survival.