evaluation and diagnosis of prognostic factors affecting the survival of leukemia patients using cumulative incidence function

Background: acute lymphoblastic leukemia (all) accounts for 25% of cancers among children less than 15 years of age. this study aimed to evaluate and determine the prognostic factors affecting the survival of leukemia patients using cumulative incidence function.method: this was a retrospective study done on 176 children under 15 who had all between 2011 and 2019. overall survival, event-free survival, disease-free survival (dfs), and non-relapse mortality served as the study’s endpoints. using the fine-gray model, the kaplan-meier, single-variable, and multivariable analyses were conducted. schwenfeld weighted residuals were used to test the proportional hazard hypothesis. sas was used to conduct the analysis.results: the hazard ratio (hr) of dfs for effective variables was calculated (girls compared to boys: 0.37 [95% confidence interval (ci): 0.15-0.91], positive testis test: 10.34 [95% ci: 4.44-24.05], children with central nervous system involvement: 2.95 [95% ci: 1.36-6.40], testicular swelling in children: 11.54 [95% ci: 4.21-31.59], children with hepatosplenomegaly larger than 2 cm: 0.30 [95% ci: 0.10-0.88], high risk of disease compared to low risk: 4.76 [95% ci: 1.12-20.22], children with complete remission in 28th day compared with no complete remission: 0.10 [95% ci: 0.04- 0.25]. only hemoglobin was substantially linked with dfs in the multivariate dfs hr. children who got radiation had a 77% reduced risk of non-recurrence death than those who did not (hr: 0.23, 95% ci: 0.08-0.60).conclusion: being a girl, having family history, and not having radiotherapy were the main factors to develop death before the first recurrence in children.