ccr4 1014c/t and ccl22 16c/a genetic variations in iranian patients with thyroid cancer

Background: the aim of this study was to investigate the association between thyroid cancer and 16c/a single nucleotide polymorphism (snp) in c-c motif chemokine 22 (ccl22) as well as 1014c/t snp in c-c chemokine receptor type 4 (ccr4).method: in this case-control study, polymerase chain reaction restriction-fragment length polymorphism (pcr-rflp) was performed for 113 thyroid cancer patients and 112 age-sex matched healthy controls to investigate the genotype distribution.results: at position 16c/a in ccl22, 95 patients (84.3%) were found to have cc genotype, while 17 individuals (14.8%) inherited ca genotype and 1 (0.9%) had aa genotype. in the control group, 92 volunteers (82.1%) inherited cc genotype, 18 individuals (16.1%) had ca genotype, and 2 (1.8%) had aa genotype. the frequency of cc, ct, and tt genotypes of 1014c/t snp in ccr4 gene was 60 (53.1%), 43 (38.1%), and 10 (8.8%) in the patients, and 57 (53.3%), 43 (40.2%), and 7 (6.5%) in the control group, respectively. there were no statistically significant differences between the patients and controls in terms of 16c/a polymorphism in ccl22 (p = 0.816) and 1014c/t snp in ccr4 1014c/t gene position (p = 0.801). nevertheless, the study of their association indicated that inheriting the cc genotype of ccr4 was significantly associated with higher stages (stages 3 and 4) in thyroid cancer.conclusion: 1014c/t genetic variation in ccr4 and 16c/a polymorphism in ccl22 were not found to have a role in genetic susceptibility to thyroid cancer. inheriting cc genotype at 1014 locus in ccr4 may; however, affect cancer progression in patients with thyroid cancer.