Relationship between Clinicopathologic Features and Recurrence in OvarianGerm Cell Tumor

Background: we conducted the present study to analyze the clinicopathologic features of patients with malignant ovarian germ cell tumor (mogct) with recurrence after 2 and 5 years.method: in this retrospective and analytical-descriptive study, the obtained data included: age, tumor size, histopathological type, tumor stage, lymph node involvement, laterality of tumor, tumor necrosis, and mitosis. we also evaluated the cox regression analysis between these variables with recurrence after 2 and 5 years.results: according to our exclusion criteria, we eliminated 81 cases. these cases consisted of the subjects with dysgerminoma (48.1%), immature teratoma (22.2%), yolk sac (16%), mix germ cell (11.1%), non-gestational choriocarcinoma (1.2%), and embryonal carcinoma (1.2%). we did not observe pure polyembryoma or polyembryoma in combination with mixed germ cell. all the patients received the treatment. the patients’ mean age was 23.3±8.4 years. mogct reoccurred in 10 patients after 2 years and in 13 patients after 5 years (10 cases in the first 2 years, and 3 new cases in the next 3 years). most of the cases (64.2%) were diagnosed to be at stage 1. the cox regression analysis between positive lymph node and the recurrence of mogct after 2 years and between stage iv of disease and the recurrence after 2 years were significant. the cox regression analysis between laterality, mitosis and necrosis in pathologic slides of the recurrence after 2 and 5 years was not significant.conclusion: stages and involvement of lymph nodes are two major factors concerning the recurrence of mogct. most recurrences occur in the first 2 years. pathologic features (mitosis and necrosis) of mogct in the time of diagnosis not correlated with the recurrence of the disease.