A Bone Marrow Study; Report ofChromosomal Variations in HematologicMalignancies Including Acute MyeloidLeukemia, Acute Lymphoid Leukemia, andMyelodisplastic Syndrome (Northeast Iran)

Background: chromosomal aberrations which occur in different hematologicmalignancies are believed to be highly applicable for identifying the prognosis andtreatment protocols. we conducted the present study to investigate the chromosomaland molecular abnormalities in bone marrow of acute myeloid leukemia (aml),acute lymphoid leukemia (all), and myelodysplastic syndrome patients.method: we performed this cross-sectional study in molecular pathology andcancer research center of mashhad university of medical sciences (mums), during2017-2019; the total number of our cases was 252. we did all the molecular andcytogenetic tests on these patients. spss v.16 software was utilized for the analysisof our data.results: in this research, the all patients were meaningfully younger than amlones. there were significant associations between karyotype patterns and types ofmalignancy; normal diploid was more frequent in myelodysplastic syndrome (p<0.05).among numerical abnormalities, trisomy 3 and monosomy 14 were the most prevalentones.conclusion: the results of similar studies from different areas with differentethnics would help to identify new parameters for prognosis determination. cytogeneticanalysis is highly applicable for leukemia diagnosis and prognosis.