Immunohistochemistry-Based MolecularSubtyping of Breast Carcinoma in IndustrialPopulation in India, Haryana: A Correlationwith Clinicopathological Parameters

Background: breast carcinoma is the most prevalent malignancy in femalesglobally and also the leading cause of cancer-related mortality. the immunohistochemistry(ihc)-based molecular subtyping has put newer insights into the biologicalbehaviour and clinical management of breast carcinoma.we conducted the present study to correlate the four ihc-based molecular subtypes:luminal a, luminal b, human epidermal growth factor receptor 2 positive, and triplenegative breast carcinoma with various clinicopathological parameters amongst theindustrial population of haryana.method: this cross-sectional study was conducted on 92 cases of invasive breastcarcinoma, who underwent modified radical mastectomy over a period of 2.5 yearswith the prior approval of institutional ethical committee at esic medical collegeand hospital, faridabad. we performed routine histopathological examination alongwith ihc (estrogen receptor, progesterone receptor and human epidermal growthfactor receptor 2) study. the correlation of the four molecular subtypes with variousclinicopathological parameters were also studied. we analysed the data using spsssoftware.results: the mean age of the patients in this study was 47 years with a maximumnumber of cases in the 3rd and 4th decade of their life. the most common subtype wasluminal b (40.9%) with the maximum number of cases presenting in stage ii (53.26%)and with grade ii (51.1%). triple-negative breast cancer was found to be associatedwith brisk mitosis, lymphovascular invasion (66.67%), necrosis (77.78%), and ductalcarcinoma in situ (66.67%). these findings were clinically significant. (p<0.05)conclusion: the early age of presentation of breast carcinoma in the industrialpopulation would warrant the need to focus on various molecular subtypes and clinicopathologicalparameters that may have different prognostic implications in thispopulation.