The Relationships between the Alteration ofMAP1LC3B, and BECN1 Gene Expressionwith Minimal Residual Disease in AcuteLymphoblastic Leukemia Patients

Background: acute lymphoblastic leukemia (all) is known as a sort of malignancyin the blood lymphoid progenitors, specifically in b and t precursors of the lymphocyte.autophagy is a protected hemostatic and catabolic process during evolution, throughwhich lysosomes degrade the cytoplasmic components, such as redundant ordysfunctional organelles and misfolded proteins. we conducted the present study toinvestigate the link between gene expression changes of becn1, map1lc3b, andp62 as the main regulators of remission and response to chemotherapy in all patientswith minimal/measurable residual disease in all.method: in this case-control study, becn1, map1lc3b, and p62 gene expressionwere assessed in 30 all patients at the diagnosis phase, 18 patients on day 15 of thetherapy, and 11 controls employing qrt-pcr.results: the results revealed that becn1and map1lc3b gene expression levelswere significantly lower in all patients; whereas, p62 gene expression levels weresignificantly higher than the controls (p < 0.05). we found that the expression levelof the becn1 and p62 genes increased and decreased respectively in patients on day15 of the therapy compared with newly diagnosed all patients. nevertheless, neitherbecn1 nor p62 genes were significantly different at the rate of 0.73-fold (p > 0.05).conclusion: our study demonstrated the relationship between autophagy-relatedmarkers, such as becn1, map1lc3b, and p62 with pathogenesis in iranian childrenwith all. we found that becn1and map1lc3b genes significantly decreased innewly diagnosed all patients and may play a part in all pathogenesis.