Prognostic Role of Epithelial Mesenchymal Transition Transcription Factors in Carcinoma- A Systematic Review and Meta-Analysis

Background: we conducted the present meta-analysis to delineate the prognostic significance of epithelial to mesenchymal transition- transcription factors in carcinoma patients. method: for the determination of the pooled hazard ratio (hr) values based on the fixed- effects model, in this retrospective study, we employed comprehensive meta-analysis software. results: this retrospective analysis identified the expression patterns of 6645 patients in 36 studies. expression of twist1 correlated with the least prognosis rate (hr= 2.129, 95% ci= 1.373 - 3.302) as compared to snail1 (hr= 1.804, 95% ci= 1.151 - 2.827), slug (hr= 1.724, 95% ci= 0.992 - 2.997) and zeb1 (hr= 1.590, 95% ci= 1.358 - 1.861). conclusion: these findings suggested the implication of twist1 as an effective biomarker for an early tumor diagnosis and therapy for metastasis.