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Treatment-related Complications in Childhood Acute Lymphoblastic Leukemia: Results of Medical Research Council UKALL X
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نویسنده
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shahverdi ehsan ,karami pedram ,tavakoli farzaneh ,maki massoumeh ,moazzami meysam ,feizi fatemeh ,salamati peyman ,lotfipour alireza ,ehsani mohammad ali
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منبع
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middle east journal of cancer - 2020 - دوره : 11 - شماره : 2 - صفحه:168 -173
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چکیده
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Background: acute lymphoblastic leukemia (all) is a heterogeneous group of lymphoid neoplasms resulting from the proliferation of malignant lymphoid cells. the aim of this study was to evaluate treatment-related complications in children with all receiving the medical research council (mrc) ukall x protocol. methods: in this retrospective cross-sectional study, children with all receiving the mrc ukall x protocol from 2008 to 2015 in bahrami university hospital, iran, were enrolled. the clinical and morphological features were analysed and treatment-related complications were assessed. results: out of 67 children with all receiving the mrc ukall x protocol, 44 (65.6 %) were boys and 23 (34.4%) were girls. seven patients (10.7%) relapsed in the three years of diagnosis, and 50 children (74.6%) had an overall survival of three years. average age in three-year-survival group and mortality group was 6.92 (sd: 3.96) and 6.35 (sd: 7.47), respectively (p= 0.38). conclusion: overall survival and relapse rates in this study confirm that this protocol is an appropriate treatment strategy.
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کلیدواژه
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Acute lymphoblastic leukemia (ALL) ,Mortality ,MRC UKALL X ,Neutropenia ,Pediatric
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آدرس
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bonifatius hospital lingen, department of cardiology, angiology and sleep medicine, Germany, iran university of medical sciences, rasoul akram hospital, department of otorhinolaryngology-head and neck surgery, Iran, shahid beheshti university of medical sciences, hematopoietic stem cell research center, Iran, islamic azad university, falavarjan branch, department of nursing and midwifery, Iran, iran university of medical sciences, firouzgar hospital, department of pediatrics, Iran, shahid beheshi university of medical science, school of allied medical sciences, department of laboratory hematology and blood bank, Iran, tehran university of medical sciences, department of pediatrics, Iran, tehran university of medical sciences, department of pediatrics, Iran, tehran university of medical sciences, department of pediatrics, Iran
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Authors
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