The Relationship of XPA and XPC Gene Polymorphisms with the Risk of Colorectal Cancer in Iran

Background: the objective of this study was to investigate the effect of several xpa and xpc polymorphisms on the risk of colorectal cancer (crc) in northeastern iran.method: 180 crc patients and 160 healthy subjects participated in this case-control study. we determined the genotypes by rflp-pcr and pira-pcr, and analyzed the results using logistic regression and χ2-test.results: our findings showed that only bmi could affect the risk of cancer among the studied demographic factors. three of the four polymorphisms studied, namely xpa a23g, xpc rs2228000 c > t and xpc rs2228001 a > c, did not correlate with crc (p-values > 0.05); however, the polymorphism of xpc poly at (pat) increased the risk of crc (p= 0.024). the xpc rs2228000 c> t polymorphism increased the crc risk only in patients aged 50 or more. the risk of crc in heterozygote individuals (xpc pat d/i) was higher than that of homozygous individuals (xpc pat d/d); also, at least one pat i variant allele increased the likelihood of crc (for pat d/i or =2.168; 95% ci = 1.809-4.319: and for pat d/i and pat i/i or = 1.810; 95% ci = 1.165-2.813). the xpc haplotypes were similar between the cases and controls, and p-values were >0.05.conclusion: in the whole population, xpc pat polymorphism, overweightness, and xpc rs2228000 c>t polymorphism in elderly people are related to crc. therefore, they can probably be considered as markers of crc in iran.