FOXP^3 Genetic Variation at Position -2383 C/T (rs3761549) in Patients with Breast Cancer

Background: we investigated the possibility of an association between the c-2383t polymorphism (rs3761549) in the promoter region of the foxp3 gene with breast cancer. methods: the study groups consisted of 250 women diagnosed with breast cancer (case group) and 250 healthy women (control group). polymerase chain reactionrestriction fragment length polymorphism was performed for genotyping. results: breast cancer cases had a c allele frequency of 455 (91%) and t allele frequency of 45 (9%). the control group had a c allele frequency of 468 (93.6%) and 32 (6.4%) for the t allele. the cc genotype was present in 206 (82.4%) patients, 43 (17.2%) patients had the ct genotype, and the tt genotype was observed in 1 (0.4%) patient. in the control group, 219 (87.6%) had the cc genotype, whereas 30 (12%) had the ct genotype, and 1 (0.4%) had the tt genotype. statistical analysis revealed no significant differences in the distribution of alleles and genotypes between patients and controls (p>0.05). there was no significant association between genotype distribution and patients' clinicopathological factors. conclusion: our results do not support an association between the foxp3 -2383 c/t polymorphism and breast cancer in a population from southern iran.