Correlation between Certain Klotho Gene Polymorphisms and IGF-1 Levels of Colorectal Cancer Patients in Northern Iran

Background: colorectal cancer susceptibility may correlate with the klotho gene g-395a and c1818t polymorphisms. this study aims to evaluate the relationship between a klotho single nucleotide polymorphism and igf-1 with risk of colorectal cancer. methods: this study enrolled 60 colorectal cancer patients and 60 age-matched healthy persons who referred to razi hospital, rasht, and northern iran in september 2013. patients enrolled under supervision of a gastro-intestinal specialist and according to the ethics right. g-395a and c1818t polymorphisms were genotyped with polymerase chain confronting two pair primer technology. igf-1 and certain biochemistry analytes were assayed. statistical analysis was used to compare appropriate relationships. results: there were different base pair partitions for g395a and c1818t. odds ratio and 95% confidence interval were used to analyze the correlation of genotypes and haplotypes with colorectal cancer susceptibility. the aa (odds ratio: 1.437, 95% confidence interval: 0.596) and ga (odds ratio: 1.958, 95% confidence interval: 1.133- 3.385) genotypes of the g-395a polymorphisms showed a slight relationship to the risk of colorectal cancer. the a allele had a much higher frequency in the case group (31.2%) compared with the control group (17.6%). there was no significant relationship with the c1818t polymorphism between the case and control groups. conclusion: the klotho gene polymorphism did not significantly increase the risk of colorectal cancer. therefore, these genotypes might not have a correlation with igf-1.