Survival Analysis in Patients with Nonmetastatic Squamous Cell Carcinoma of the Urinary Bladder

Background: we conducted a retrospective analysis to evaluate overall survival (oas) and disease free survival (dfs) rates in patients with squamous cell carcinoma of the urinary bladder according to different prognostic factors. methods: this retrospective study analyzed the medical records of patients with non-metastatic squamous cell carcinoma of the urinary bladder. all men underwent radical cystectomy and women underwent anterior pelvic exentration. most patients had postoperative radiation therapy. the log-rank test examined differences in oas and dfs rates. results: the medical records of 106 patients were analyzed. the median follow- up from the date of enrollment was 30 months and ranged from 2 to 73 months. for the entire group, three-year oas rates were 46.9% and dfs rates were 44%. for patients with p2 (tumor invasion into the muscularis propria) the three-year oas rate was 53%, for p3 (tumor invasion into perivesical fat) it was 45% and 9% for p4 (tumor invasion into adjacent organs, pelvic wall or abdominal wall) the oas rate was statistically significant in favor of p2 disease (p=0.0041). the three-year dfs rate was 50% for p2, 45% for p3 and 9% for p4 disease (p=0.0125). administration of post-operative radiotherapy did not result in statistically significant improvement in three-year oas and dfs rates. conclusion: survival rates were statistically significant and higher in patients with p2 and p3 disease compared to p4 disease. adjuvant radiotherapy did not result in statistically significant survival improvement.