Limbic encephalitis driven by a pleural mesothelioma: A paraneoplastic complication

Paraneoplastic neurological syndromes have only been described with pleural mesothelioma in five cases. we have described a 72-year-old man who developed anterograde amnesia 27 months after diagnosis of epithelioid pleural mesothelioma. investigations revealed a limbic encephalitis with no alternative causes identified. limbic encephalitis is a classical paraneoplastic syndrome and presentation within five years of a cancer with no other causes identified is sufficient to diagnose a paraneoplastic etiology. this is the first case of isolated paraneoplastic limbic encephalitis driven by a pleural mesothelioma. © 2016,shiraz university of medical sciences. all rights reserved.