comparing the apelin level in hypertensive patients who received hypertension drugs

Background: apelin, an adipokine secreted from adipose tissue, plays an important role in regulating blood pressure and hypertension.[objectives]the current study aimed to compare the plasma apelin level in hypertensive patients under treatment with amlodipine, losartan, and amlodipine + losartan.[methods]in this casecontrol study, the serum level of apelin was compared in four groups of (a) healthy subjects (n = 31); (b) hypertensive patients, received amlodipine (n = 31); hypertensive patients, received losartan (n = 45); and patients (n = 33) that received amlodipine and losartan. apelin level in serum samples was measured using human apelin elisa kit according to the manufacturers’ instructions. data were analyzed using spss version 19 (chicago: spss inc.), at the significant level of α = 0.05.[results]the mean blood level of apelin in the control group and groups receiving amlodipine, losartan, and amlodipine + losartan was 366.16 ± 36.04, 247.19 ± 27.77, 282.93 ± 47.08, and 289.84 ± 32.20 g/dl, respectively. losartan + amlodipine group had a higher level of apelin compared with amlodipine alone (p lt; 0.05).[conclusions]this study demonstrated that apelin has a definite protective effect in preventing hypertension. also, according to the results, the reninangiotensinaldosterone system inhibitors, such as losartan, caused a higher increase in the apelin, resulting in better blood pressure control.