protective role of training and selenium consumption against renal toxicity induced by cadmium in rats

Background: cadmium is a toxic metal, which can cause damage to the renal tissue. various studies have suggested the protective role of training and selenium as a cofactor involved in the production of antioxidants in acute and chronic kidney disease, although the molecular-cellular mechanism of these two interventions is still not fully understood in the renal tissue. objectives: the aim of this study was to investigate the protective effects of training and selenium consumption on the renal tissue of cadmium-poisoned rats. methods: in this experimental study, 40 rats were randomly assigned into eight groups of five rats, including: (1) control, (2) sham, (3) cadmium, (4) cadmium + selenium, (5) cadmium + continuous training, (6) cadmium + high intensity interval training (hiit), (7) cadmium + continuoustraining + selenium, and (8) cadmium + hiit + selenium. during eight weeks, rats in groups 3 - 8 received 2 mg/kg of cadmium peritoneally daily and rats in groups 4, 7, and 8 received 0.23 mg/kg of selenium per day, peritoneally. also, rats in groups 5 - 8 were given three sessions of hiit (with 80 - 110 percentage of maximum speed) and continuous training (with 50% to 75% of maximum speed) for three sessions per week. shapiro-wilk, one-way anova, two-way anova, and bonferroni’s post hoc tests were used to analyze the findings. the significance level was considered at 0.05. results: continuous training had a significant effect on reduction of albumin (alb) (p = 0.001) and total bilirubin (tbil) (p = 0.001), in addition, hiit had a significant effect on reduction of alb (p = 0.001) and tbil (p = 0.04). the results of the two-way anova test showed that selenium had a significant effect on the reduction of alb (p = 0.001), tbil (p = 0.001), and histidine ammonia-lyase (hal) (p = 0.001). in addition, training with selenium had interactive effects on the reduction of tbil (p = 0.004) and hal (p = 0.001). conclusions: it seems that continuous training and hiit, along with selenium consumption, have protective effects on the renal tissue of cadmium-poisoned rats.