anti-inflammatory effects of curcumin on insulin resistance index, levels of interleukin-6, c-reactive protein, and liver histology in polycystic ovary syndrome-induced rats

Objective: curcumin protects the liver against injury and fibrosis through suppressing hepatic inflammation, attenuating hepatic oxidative stress (os), and inhibiting hepatic stellate cells (hscs) activation. non-alcoholic fatty liver disease (nafld) and polycystic ovary syndrome (pcos) are considered as common metabolic disorders. low-grade chronic inflammation with different markers, such as elevated c-reactive protein (crp) and interleukin-6 (il-6) levels, play a crucial role in pcos. this study aimed to evaluate the therapeutic effects of curcumin on il-6 and crp levels as well as insulin resistance (ir) index on liver function in pcos rats. materials and methods: in this experimental study, 90 adult wistar rats were divided into control (n=18), sham (n=18), pcos (n=18) and curcumin-treated pcos groups (n=36). pcos group was injected subcutaneously with 2 mg estradio-valerate (e2v). after 60 days, pcos group was treated with curcumin [100 and 300 mg/kg body weight (bw)] for 14 days and anesthetized by chloroform. blood and liver samples were collected for histological and serological analyses. data were analyzed using in-stat 3 via one-way analysis of variance (anova). results: histological and serological analyses showed a reduction in number of necrotic cells, ir index, as well as il-6 and crp levels in pcos rats that were treated with various concentrations of curcumin. conclusion: in this study, curcumin decreased liver inflammation by induction of insulin sensitivity and reduction of hepatic necrosis. therefore, curcumin may be considered as protective factor against inflammatory state of pcos.