Protective Effect of Royal Jelly on in Vitro Fertilization (IVF) in Male Mice Treated with Oxymetholone

Objective: this study aimed to investigate the effects of royal jelly (rj) on catalase, totalantioxidant capacity and embryo development in adult mice treated with oxymetholone(oxm).materials and methods: in this exprimental study, 32 male and 96 female adult navalmedical research institute (nmri) mice (7-9 weeks of age) with a ratio of 1:3 for fertilizationpurposes were randomly divided into 4 groups as follows: i. control group (n=8)receiving 0.1 ml/mice saline daily by gavage for 30 day, ii. rj group (n=8) treated with rjat a dose of 100 mg/kg daily by gavage for 30 days, iii. oxm group (n=8) receiving oxmat the dose of 5 mg/kg daily by gavage for 30 days and iv. rj+oxm group (n=8) receivingrj at the dose of 100 mg/kg daily by gavage concomitant with 100 mg/kg oxm administrationfor 30 days.results: analysis revealed a significant reduction in catalase, total antioxidant, aswell as embryo development in oxm group (p < 0.05). however, rj group showed asalient recovery in the all of the above mentioned parameters and embryo toxicity.conclusion: the results of this study indicated a partially protective effect of rj againstoxm-induced embryo toxicity.