Suppressive Effects of Resveratrol Treatment on the Intrinsic Evoked Excitability of CA1 Pyramidal Neurons

Objective: resveratrol, a phytoalexin, has a wide range of desirable biological actions.despite a growing body of evidence indicating that resveratrol induces changes in neuronalfunction, little effort, if any, has been made to investigate the cellular effect of resveratroltreatment on intrinsic neuronal properties.materials and methods: this experimental study was performed to examine theacute effects of resveratrol (100 ?m) on the intrinsic evoked responses of rat cornuammonis (ca1) pyramidal neurons in brain slices, using whole cell patch clamp recordingunder current clamp conditions.results: findings showed that resveratrol treatment caused dramatic changes inevoked responses of pyramidal neurons. its treatment induced a significant (p < 0.05)increase in the after hyperpolarization amplitude of the first evoked action potential.resveratrol-treated cells displayed a significantly broader action potential (ap) whencompared with either control or vehicle-treated groups. in addition, the mean instantaneous?ring frequency between the ?rst two action potentials was signi?cantly lower inresveratrol-treated neurons. it also caused a significant reduction in the time to maximumdecay of ap. the rheobase current and the utilization time were both significantlygreater following resveratrol treatment. neurons exhibited a significantly depolarizedvoltage threshold when exposed to resveratrol.conclusion: results provide direct electrophysiological evidence for the inhibitoryeffects of resveratrol on pyramidal neurons, at least in part, by reducing the evokedneural activity.