Protective Effects of Diallyl Sulfide and Curcumin Separately Against Thallium-Induced Toxicity in Rats

Thallium acetate (ti) is a cumulative poison intimately accompanied by an increase inreactive oxygen species (ros) formation that represents an important risk factor for tissueinjury and malfunction. this study aims to determine the possible hepatoprotective andantioxidant effects of diallyl sulfide (das) from garlic and curcumin from turmeric againstti-induced liver injury and oxidative stress (os) in rats.this in vivo animal study divided rats into six groups of 8 rats per group. the firstgroup received saline and served as the control group. the second and third groupsreceived das or curcumin only at a dose of 200 mg/kg. the fourth group receivedti at a dose of 6.4 mg/kg for 5 consecutive days. the fifth and sixth groups receiveddas or curcumin orally 1 hour before ti intoxication at the same dose as the secondand third groups. liver integrity serum enzymes aspartate aminotransferase (ast),alanine aminotransferase (alt), alkaline phosphatase (alp), lactate dehydrogenase(ldh), and ?-glutamyltransferase (?-gt) were evaluated. serum and liver tissuehomogenate lipid peroxidation and os biomarkers were measured. the data wereanalyzed by one-way anova followed by duncan’s multiple range test for post hocanalysis using spss version 16.ti induced marked oxidative liver damage as shown by significantly (p?0.05) elevatedserum ast, alt, alp, ldh and ?-gt levels. there were significant (p?0.05) increasesin serum and hepatic malondialdehyde (mda) and serum nitric oxide (no) as well asdecreased hepatic glutathione (gsh) and catalase (cat) activities. there were significantly(p?0.05) less serum and hepatic superoxide dismutase (sod) and total antioxidantcapacity (tac). pre-treatment with das or curcumin ameliorated the changes in moststudied biochemical parameters. das and curcumin effectively reduced ti-induced livertoxicity.