Modulating Effects of Spirulina platensis against Tilmicosin-Induced Cardiotoxicity in Mice

Objective: tilmicosin (til) is a long-acting macrolide antibiotic used to treat cattle forpathogens that cause bovine respiratory disease. however, overdoses of this medicationhave been reported to induce cardiac damage. our experimental objective was to evaluatethe protective effects of spirulina platensis (sp) administration against til-inducedcardiotoxicity in mice.materials and methods: our experimental in vivo animal study used 40 male albino micethat were divided into five groups of eight mice per group. the first group served as a controlgroup and was injected with saline. the second group received sp at dose of 1000 mg/kgbody weight for five days. the third group received a single dose of til (75 mg/kg, subcutaneously).groups 4 and 5 were given sp at doses of 500 and 1000 mg/kg body weight for fiveconsecutive days just before administration of til at the same dose and regimen used forgroup 3.results: til treated animals showed a significant increase in serum cardiac injury biomarkersas well as cardiac lipid peroxidation, however they had evidence of an inhibition in antioxidantbiomarkers. sp normalized elevated serum levels of lactate dehydrogenase (ldh),creatine kinase (ck), and ck-mb. furthermore, sp reduced til-induced lipid peroxidationand oxidative stress in a dose-dependent manner.conclusion: administration of sp minimized the toxic effects of til by its free radicalscavengingand potent antioxidant activity.