Effects of An Eight-Week Resistance Training on Plasma Vaspin Concentrations, Metabolic Parameters Levels and Physical Fitness in Patients With Type 2 Diabetes

Vaspin as a novel adipokine has insulin-sensitizing effects, which may be associated with decreasedblood glucose concentration. in this study, we aimed to investigate the effects of resistanceexercise training on plasma vaspin concentrations and its relation to plasma levelsof insulin and glucose in patients with type 2 diabetes (t2d). in a quasi-experimental study,18 male patients with t2d (mean age, 48.50 ± 7.73 years, mean weight, 79.41 ± 12.60 kg)were divided into 2 groups as follows: control (n=9), and resistance training (rt; n=9) groups.resistance training was performed 3 times weekly for 8 weeks. anthropometric, metabolicparameters and plasma vaspin levels were measured at baseline and at the end of study.within-group data were analyzed with the paired t test, and between-group effects were analyzedwith the independent t test. waist-hip ratio (whr), glucose, insulin of plasma and insulinresistance [homeostasis model assessment of insulin resistance (homa-ir) score] were allsignificantly decreased, whereas levels of vaspin and plasma lipids [cholesterol, triglycerides(tg), high-density lipoprotein (hdl), low-density lipoprotein (ldl) and very low-density lipoproteins(vldl)] showed no significant changes in rt group as compared with the relatedvalues of control groups. serum vaspin levels did not correlate with anthropometric and metabolicparameters at the assigned times. our findings suggest that 8-week of resistance trainingsignificantly improved insulin resistance index; however, this form of exercise failed to result insignificant changes in serum vaspin concentration and lipid profiles. further research is neededto investigate the role of vaspin in human physiology and to elucidate the effect(s) of exerciseintervention on serum vaspin concentrations (registration number: irct2013060911772n1).