Total Antioxidant Capacity and Lipid Peroxidation in Semen of Patient with Hyperviscosity

Semen hyperviscosity (shv) is one of the factors involved in deficiency in sperm function.this research aimed to evaluate seminal plasma total antioxidant capacity (tac)and malondialdehyde (mda) levels in infertile patients with hyperviscous and non-hyperviscoussemen samples to understand whether hyperviscous semen is associated withoxidative damage in infertile subjects. in this cross sectional study, 59 semen sampleswere provided by fertile (n=12) individuals as control, infertile patients with normal viscosity(n=25) and infertile patients with hyperviscosity (n=22). after semen parameters examination,semen viscosity was studied by glass pipettes. seminal plasma tac and mdalevels were measured by ferric reducing of antioxidant power (frap) and thiobarbituricacid reaction (tbar) methods, respectively. a probability less than 0.05 was consideredstatistically significant throughout the article. the mean of sperm parameters including:counts, motility and normal morphology in patients with hyperviscosity were significantlylower than those in non-hyperviscosity patients (p < 0.05, p < 0.01 and p < 0.001, respectively).the mean of seminal plasma tac value in seminal plasma of non-hyperviscositypatients (1710.31 ± 458.67 ?mol/l) was significantly (p < 0.01) higher than that of hyperviscositygroup (1230.25 ± 352 ?mol/l). a trend toward a higher mean of seminal plasmamda value was estimated for hyperviscous group compared with non-hyperviscous (1.01± 0.41 nmol/ml vs. 0.94 ± 0.28 nmol/l); however, it was nonsignificant. hyperviscous semenimpairs seminal plasma tac which is eventually associated with sperm membranelipid peroxidation.