Protection of Renal Tubular Cells By Antioxidants: Current Knowledge and New Trends

Acute renal damage mainly develops following toxic or ischemic insults and is defined asacute. these damages have largely been attributed to oxidative stress. recently muchattention has been directed toward decreased renal tubular cell regeneration during tubularcell injury. antioxidants have recently been the focus of researchers and scientistsfor prevention and treatment of various oxidative stress-related conditions, including renaltoxicities. although free radicals are known to contribute in kidney injury and abundantresearches, particularly laboratory trials, have shown the beneficial effects of antioxidantsagainst these complications, long term clinical trials do not uniformly confirm this matter,especially for single antioxidant consumption such as vitamin c. the aim of this paper isto discuss the possible explanation of this matter.