The Relationship Between Salivary Beta-2 Microglobulin and Uremia Intensity in Men With Chronic Renal Failure

Objective: this study defines the relationship between salivary beta-2 microglobulin (b2-m) and intensity of uremia in male patients diagnosed with chronic renal failure (crf).materials and methods: in total of 42 males were enrolled in a case-control study. there were 21 cases of crf and 21 control cases. we collected 10cc of saliva plus 5 cc of blood from all patients to determine b2-m, blood urea nitrogen (bun) and creatinine(cr) levels.results: there was a correlation between the level of serum bun and salivary urea in controls and patients, which was statistically significant for controls (p=0.028).the correlationbetween serum and salivary cr was 0.195 in controls (p=0.398) and 0.598 in patients (p=0.006), which was statistically significant in patients. the correlation between serum and saliva was 0.133 (p=0.566) in controls and 0.078 (p=0.737) in patients, which was not statistically significant. the correlation between serum bun and b2-m was 0.168 (p=0.469) in the control group and 0.629 (p=0.002) in patients, which was statistically significant in patients. the correlation between serum cr and b2-m was 0.110 (p=0.635) in the control group and 0.678 (p=0.001) in patients, which was statistically significant in patients. the correlation between serum bun and salivary b2-m was 0.093 (p=0.0690) in controls and 0.152 (p=0.152) in patients, which was not statistically significant. the correlationbetweenserumcrandsalivaryb2-mwas0.072(p=0.070)inthecontrolgroupand0.286(p=0.209) in patients, which was not statistically significant in either group.conclusion: the results of the study indicated that salivary b2-m cannot be used as a noninvasiveindicator to detect the severity of renal failure.