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   clinical implications and prognostic value of leucine-rich g protein-coupled receptor 5 expression as a cancer stem cell marker in malignancies: a systematic review and meta-analysis  
   
نویسنده ghobakhloo sepideh ,khoshhali mehri ,vatandoost nasimeh ,jafarpour sima ,niazmand anoosha ,nedaeinia reza ,salehi rasoul
منبع cell journal (yakhteh) - 2024 - دوره : 26 - شماره : 1 - صفحه:1 -12
چکیده    Leucine-rich g protein-coupled receptor 5 (lgr5) is a marker of cancer stem cells (cscs) in various cancers. based on different studies, conflicting reports exist on correlation between lgr5 expression and poor prognosis/ clinicopathological parameters in cancer patients. therefore, our purpose in conducting this study was to investigate correlation between lgr5 expression and outcomes of cancer patients under study through a systematic review and meta-analysis. relevant articles were searched and collected using embase, pubmed, science direct, and scopus databases until december 21, 2022. this study was conducted to examine correlation between lgr5 expression and different clinical outcomes, such as recurrence-free survival (rfs), disease-free survival (dfs), overall survival (os), and clinicopathological characteristics of the included cancer patients. to achieve this, hazard ratios (hrs) with 95% confidence intervals (cis) and odds ratios (ors) with 95% cis were used as statistical measures. a meta-analysis was conducted using stata 12.0 software. finally, 53 studies including 9523 patients met the inclusion criteria. significantly, high-level expression of lgr5 was related to poor prognosis in terms of os, higher tumor stage, presence of distant metastasis, and presence of lymph node metastasis. it was discovered through subgroup analysis that several factors, including the study area, evaluation method, and type of cancer, can influence the correlation between lgr5 expression and negative prognosis in cancer patients. according to the results of our study, lgr5 overexpression was related to poor os in cancer patients. in addition, clinicopathological data indicated an unfavorable prognosis in cancer patients with high lgr5 expression. in conclusion, lgr5 may serve as a potential prognostic marker for predicting survival in certain cancer types.
کلیدواژه cancer stem cells ,clinicopathological features ,lgr5 ,prognostic marker
آدرس isfahan university of medical sciences, school of medicine, pediatric inherited diseases research center, research institute for primordial prevention of non-communicable diseases, department of genetics and molecular biology, iran, isfahan university of medical sciences, child growth and development research center, research institute for primordial prevention of non-communicable disease, iran, isfahan university of medical sciences, school of medicine, pediatric inherited diseases research center, research institute for primordial prevention of non-communicable diseases, department of genetics and molecular biology, iran, isfahan university of medical sciences, school of medicine, pediatric inherited diseases research center, research institute for primordial prevention of non-communicable diseases, department of genetics and molecular biology, iran, isfahan university of medical sciences, school of medicine, department of genetics and molecular biology, iran, isfahan university of medical sciences, pediatric inherited diseases research center, research institute for primordial prevention of non-communicable diseases, iran, isfahan university of medical sciences, school of medicine, pediatric inherited diseases research center, research institute for primordial prevention of non-communicable diseases, department of genetics and molecular biology, iran
پست الکترونیکی r_salehi@med.mui.ac.ir
 
     
   
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