healthy male individuals possess higher plasma her-2 level than females

Considering her2 as one of the well-known biomarkers in the cancer field, and published articles regarding serumlevels of her2, in this paper we tried to highlight the issue that most studies don’t stratify the her-2 concentrationof individuals in terms of gender. in this brief survey, healthy individuals with no prior non-communicable diseaseswere categorized as males (n=34) and females (n=43), and all samples were evaluated for plasma her-2 levelsat once. surprisingly, the plasma level of her-2 of healthy male individuals (mean= 2.28 ± 0.21 ng/ml) wassignificantly (p<0.0001) higher than the plasma level of her-2 of healthy females (mean: 0.06 ± 0.09 ng/ml),with no overlap. therefore, we suggest that more studies are required to re-check the cutoff values for her-2plasma levels based on gender since the clinical implications of a unique her-2 cutoff for both genders may beseriously concerning.