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inhibitory effect of the haspin inhibitor chr-6494 on bxpc-3-luc,a luciferase-expressing pancreatic cancer cell line
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نویسنده
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tanaka hiromitsu ,nishida-fukuda hisayo ,wada morimasa ,tokuhiro keizo ,matsushita hiroaki ,ando yukio
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منبع
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cell journal (yakhteh) - 2022 - دوره : 24 - شماره : 4 - صفحه:212 -214
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چکیده
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Haspin acts in chromosome segregation via histone phosphorylation. recently, haspin inhibitors have been shown to suppress growth of various cancer cells. pancreatic cancer has no symptom in the early stages and may progress before detection. so, the 5-year survival rate is low. here, we reported that administration of the haspin inhibitor, chr-6494, to mice bearing pancreatic bxpc-3-luc cancer cells significantly suppressed growth of bxpc-3-luc cells. chr-6494 might be a useful agent for treating pancreatic cancer.
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کلیدواژه
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haspin kinase ,histone h3 ,pancreatic cancer ,protein kinase
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آدرس
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nagasaki international university, faculty of pharmaceutical sciences, japan, kansai medical university, institute of biomedical science, department of genome editing, japan, nagasaki international university, faculty of pharmaceutical sciences, japan, kansai medical university, institute of biomedical science, department of genome editing, japan, nagasaki international university, faculty of pharmaceutical sciences, japan, nagasaki international university, faculty of pharmaceutical sciences, japan
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Authors
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