Lipoprotein Lipase HindIII Intronic Polymorphism in a Subset of Iranian Patients with Late-Onset Alzheimer’s Disease

Lipid metabolism is involved in the pathogenesis of late-onset alzheimer’s disease (load). lipoprotein lipase (lpl) is a multifunctional enzyme that plays a major role in lipid metabolism; its abnormal function seems to be related, either directlyor indirectly, to the pathogenesis of many diseases such as atherosclerosis, coronary artery disease (cad) and alzheimer’s disease (ad) . hindiii polymorphism is a common lpl genetic variant shown to increase the risk of load. the present research investigates whether this polymorphism is involved in the pathogenesis of iranian load patients.materials and methods: in this case control study ,allele and genotype frequencies for the hindiii polymorphism of the lpl gene in 100 patients affected with load and 100 healthy controls were determined by reaction-restriction fragment length polymorphism (pcr-rflp) and compared using the chi-square and fisher’s exact tests.results: lpl h+h+ genotype frequency in load patients was 58%, which was significantlyhigher than controls (44%). there was a 1.75-fold increased risk for the development of load in carriers of the h+h+ genotype compared to non-carriers (or=1.75; 95%ci: 1.00-3.07; p=0.048). when adjusted for sex, the h+h+ genotype was more frequent in patients than controls; this difference was more remarkable in males (or: 1.90; 95% ci: 1.08-3.34; p=0.024). the mean age of disease onset did not differ in patients with the lpl h+h+ genotype compared to unaffected individuals.conclusion: this study confirms the association between the h+h+ genotype with load and supports the correlation of this genotype of the lpl gene with risk of developing load in iranian patients with ad.