Predictors of Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes

Non-alcoholic fatty liver disease (nafld) is common in patients with type 2 diabetes and its diagnosis in clinics is based onultrasonography. the aim of this study is to examine the role of some clinical and laboratory variables in predicting nafld diagnosedby ultrasonography in patients with type 2 diabetes.material and methods: the study was performed on 76 consecutive alcohol-negative and hepatitis b and c virus-negative patients, attending an endocrine clinic; all of them had undergone a complete clinicaland biochemical work up, including demographic and anthropometric factors, lipid profiles, fasting plasma glucose, glycosilated hemoglobin (hbalc), liver transaminases and alkaline phosphatase. usingultrasonography, patients were divided into two groups, one with and the other without nafld. a logistic regression model was developed in stepwise manner to evaluate predictors of nafld.results: average age was 60±9 years. forty-nine (64.5%) patients were female. sixty-three patients (82.9%) had ultrasonography-diagnosed nafld. average body mass index (bml) was higher innafld patients (29.4±4.4 kg/m2 vs. 24.8±3.8 kg/m2, p<0.05). among age, gender, fpg, duration of diabetes, triglycerides, waist ircumference and bml, the only independent factor associated with ultrasounddiagnosed nafld was bmi [adjusted odds ratio for25<=bml<30 kg/m2: 7.8 (95% ci:1.9 to 324); bmi >= 30 kg/m2:24 (95%ci:2.6 to 223),p<0.001].conclusion: the findings demonstrate that bmi per se can be considered as an independent predictor of nafld in patients with type 2 diabetes.