A Case of Hashimoto's Thyroiditis Presenting with Chronic Upper eye Lid Retraction and Positive Calsequestrin and Collagen XIII Antibodies

The pathogenesis of thyroid-associated ophthalmopathy (tao) and themechanism for its unique link with thyroid autoimmunity are poorly understood, in part due to the absence of specific diagnostic clinical signs and confirmatory gold standard laboratory tests. we reporta patient who highlights the potential clinical role for eye muscle and collagen xiii antibody testing in the diagnosis and management of thyroid-related eye, eyelid and orbital disorders. a healthy euthyroid woman member of the thyroid research laboratory presented with the incidental finding of positive calsequestrin and collagen xiii antibody tests carried out in the context of our research. she was pregnant at thetime. examination revealed marked upper eyelid retraction (uer) and a small goitre. seven months after an uneventful pregnancy, whichwas 12 months after the initial blood test, she represented with overt hypothyroidism. thyroglobulin and microsomal antibodies werestrongly positive (25,600, > 25,600, respectively) and tsh was 40. we then tested the earlier serum sample for thyroid antibodies, which werepositive at a low titre (1600, 1600, respectively) indicating that she had hashimoto's thyroiditis at that time. the hypothyroidism persisted, requiring long term management with lthyroxine.uer can occur in the absence of other features of ophthalmopathy except for mild protopsis in patients with hashimoto's thyroiditis in whom antibodies targeting eye muscle or collagen xiii antibodies are detected in about 50% of cases. overall about 20% of patients withhashimoto's thyroiditis have eye signs. calsequestrinantibodies are specific and sensitive markers for extra ocular and upper eyelid muscle inflammation and damage in patients with thyroidautoimmunity and collagen xiii antibodies appear to be good markers for the congestive ophthalmopathy subtype of tao.