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Differential Responses to Acarbose Between Obese and Non-obese Patients with Type 2 Diabetes Mellitus
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نویسنده
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Chien-Wen Chou ,Horng-Yih Ou ,Shu-Hwa Hsiao ,Ta-Jen Wu
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منبع
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international journal of endocrinology and metabolism - 2006 - دوره : 4 - شماره : 2 - صفحه:63 -69
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چکیده
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To investigate the responses in terms of body weight, glycemic control, metabolic control, and the side effects to acarbose add-on therapy in obese and non-obese type 2 diabetes patients with inadequatelycontrolled by sulfonylureas and metformin.materials and methods: forty obese (bmi > 27) and 80 sex- and age-matched non-obese patients with type 2 diabetes mellitus were enrolled in this 3-month, open-label, case-controlled trial for acarbose add-on therapy. totally 111 (73 nonobese and 38 obese) patients completed 3-month acarbose add-on therapy. this study adopted a 2centeropen-label parallel group design. after a 4-week run-in period, acarbose was added (titrated up to 100 mg t.i.d.) to the current sulfonylureasand metformin combined therapy of subjects.both obese patients (9.3±1.3% vs, 8.3±1.6%, p
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کلیدواژه
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2 diabetes mellitus ,Acarbose ,Obesity
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آدرس
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Chi-Mei Medical Center, Division of Endocrinology and Metabolism, National Cheng Kung University Hospital, Division of Endocrinology and Metabolism, National Cheng Kung University Hospital, Department of Pharmacy, National Cheng Kung University, College of Medicine, Taiwan
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پست الکترونیکی
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djwu@mail.ncku.edu.tw
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Authors
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