Protein Tyrosine Phosphatase-Like Protein Ia2 Antibodies and Clutamic Acid Decarboxylase 65 Antibodies (GADA) are not Associated With Sarcoidosis

The existence of an association between glutamic acid decarboxylase 65 antibodies (gada) and/or ia2 antibodies and sarcoidosis was evaluated. materials and methods: 78 patients with documented sarcoidosis, divided according to the presence (n=37) or absence (n=41) of autoimmune manifestations were evaluated for gada and ia2 antibodies using, a radioligand assay with human recombinant 35s-labeled gad65 and ia2 respectively.results: two patients with gada (2.6%) and one (1.3%) with ia2ab, both in the group of patients with autoimmunity associated sarcoidosis were found. the gada positive patient had manifest type 1 diabetes that succeeded sarcoidosis. ia2 ab-positivity was seen among patients with isolated sarcoidosis. gada and ia2ab frequencies were not increased compared to reference subjects (2-3%).conclusions: no clear association between sarcoidosis and gada and/or ia2ab was found. in patients with sarcoidosis, gada seem to be associated with type 1 diabetes or other autoimmune manifestations rather than with sarcoidosis per se