Medroxyprogesterone Acetate and Progesterone, Used Short Term, Do not Adversely Affect Forearm Reactive Hyperemia in Postmenopausal Women on Estradiol Therapy

This study aimed at investigating whet-her oral medroxyprogesterone acetate (mpa) or micronized progesterone (p) combined with micronized estradiol (e2) adversely affect endothelial function in postmenopausal women. materials and methods: randomized, doubleblind, crossover trial of mpa or micronized p with oral e2 treatment in menopausal women. result: flow-mediated, endothelium-dependent vasodilation of the brachial artery was not significantly affected by short-term administration of e2 alone or e2 combined with cyclic mpa, or e2 combined with cyclic p. conclusion: short-term oral e2 treatment of postmenopausal women alone or with cyclic oral mpa or oral p did not affect flow-mediated endothelium- dependent vasodilation.