Alteration of Lipid Parameters in Patients With Subclinical Hypothyroidism

Background: overt hypothyroidism is associated with abnormalities of lipid metabolism, but conflicting results regarding the degree of lipid changes in subclinical hypothyroidism (sch) exist. objectives: the aim of this study was to assess differences in lipid profile parameters between subjects with and without sch in a north indian population. patients and methods: serum lipid parameters of 70 patients with subclinical hypothyroidism and 100 age and sex matched euthyroid controls were evaluated in a cross-sectional study. results: mean serum total cholesterol (tc), triglycerides (tg) and very low-density cholesterol (vldl) were significantly higher in patients with sch than controls (p < 0.05). mean tc, tg and low-density cholesterol (ldl) concentrations were higher in patients with serum thyroid stimulating hormone (tsh) greater than 10 mu/l than those with serum tsh equal to or less than 10 mu/l, but this difference was not statistically significant. no association was found between serum high-density cholesterol (hdl-c) concentration and serum tsh level. conclusions: high tc, tg and vldl were observed in our patients with sch.