Liver and Plasma Nesfatin-1 Responses to 6 Weeks of Treadmill Running With or Without Zizyphus Jujuba Liquid Extract in Female Rat

Background: nesfatin-1 is a protein derived from a precursor molecule of the nucleobindin-2 gene, and acts as an anorexigenic peptide on food intake behavior, and its level isinfluenced by nutritional status, food composition [fat and carbohydrate (cho)], and physical exercise. objectives: the aim of this study was to investigate the effects of 6 weeks of treadmill running (at high intensity) program with and without zizyphus jujuba (high carbohydrate content) crud extraction on liver nesfatin-1, atp, glycogen, and its plasma concentrations in female rats. materials and methods: twenty-eight wistar female rats (6-8 weeks old100-120 g of weight) were randomly assigned to salinecontrol (sc), saline-training (st), zizyphus jujuba-control (zjc), and zizyphus jujuba-training (zjt) groups. rats ran on a motor-driven treadmill at 35 m/min, 60 min/day, 5 days/week for 6 weeks. animals received zj extraction and saline at the dose of 1.25 ml/100g of body weight. seventy-two hours after the last training session rats were killed, a portion of liver excited, and plasma was collected for nesfatin-1, atp, and glycogen measurements. a one-way anova method, and pearson correlation were employed. p < 0.05 was considered as significant. results: a higher and significant liver nesfatin-1 level was found in zj groups (p < 0.005), but plasma nesfatin-1 responded differently. changes in liver nesfatin-1 were accompanied with an increase in liver glycogen,but not atp contents. conclusions: the findings indicate that higher liver nesfatin-1 and glycogen content by zj extraction might be due to the zj high cho content, and it could be consideredas an anti-appetite herb.