the association between male infertility and cardiometabolic disturbances: a population-based study

Background: further studies are needed to extend our knowledge about the association between male infertility and cardiometabolic disorders. objectives:weaimedto assess the association betweenmaleinfertilityandcardiometabolic disturbances using a population-based design. methods: in total, 1611 participants of the tehran-lipid and glucose-study (phase iii) were categorized into two groups of men with documented male infertility (n = 88) and those with at least one live birth and no history of primary infertility (n = 1523). logistic regression was applied to explore the association between male infertility and cardiometabolic disturbances, including diabetes mellitus, pre-diabetes, hypertension, metabolic syndrome, dyslipidemia, obesity, central obesity, and chronic kidney disease, following adjustment for age and body mass index (bmi). results: the unadjusted model revealed a significant association between infertility and hypertension and ckd (or = 1.8; 95% ci: 1.2, 2.9, p-value = 0.006 and or = 1.9; 95% ci: 1.1, 3.6, p-value = 0.033), respectively. however, after adjusting for age and bmi, as potential confounders, this association was not significant. moreover, there was no association between infertility and other cardiometabolic disturbances, including diabetes and pre-diabetes, metabolic syndrome, dyslipidemia, obesity, and central obesity in both unadjusted and adjusted models. conclusions: our study revealed no association between male infertility and cardiometabolic disturbances. the findings can pave the way for further studies to extend our knowledge in this field. more population-based studies with a large sample size are warranted to confirm these findings.