association between pre-transplant magnesemia and post-transplant dysglycemia in kidney transplant recipients

Background: serum magnesium (mg) status in kidney transplant recipients has been a center of attention in the past few years. current evidence suggests an association between pre-transplant hypomagnesemia and post-transplant hyperglycemia. objective: the purpose of this study was to assess the associations of pre-transplant magnesemia with blood glucose disturbances within 6 months post-kidney transplantation. methods: in this retrospective cohort, 89 first-time kidney transplant recipients with 6 months of follow-up were included. none of the participants had a positive history of rejection, pre-transplant history of diabetes mellitus or fasting plasma glucose ≥ 100 mg/dl. results: post-transplant diabetes mellitus (ptdm) and impaired fasting glucose (ifg) 6 months post-transplant was found in 7.9% and 41.6% of the study group, respectively. the mean pre-transplant serum mg level was 1.92 ± 0.30 mg/dl in the study population (n = 89), and it was significantly lower in ifg (n = 37) and ifg/ptdm (n = 44) groups compared to normoglycemic (n = 45) recipients (1.83 ± 0.31 mg/dl vs. 2.00 ± 0.27 mg/dl, p = 0.008, and 1.84 ± 0.31 mg/dl vs. 2.00 ± 0.27 mg/dl, p = 0.012, respectively). patients with serum mg less than 1.9 mg/dl were nearly 2.6 times more likely to develop ifg or ifg/ptdm within 6 months post-transplant (p = 0.044 and p = 0.040, respectively). conclusions: pre-transplant hypomagnesemia may be considered a risk factor for developing post-transplant glycemic disturbances, and patients with lower pre-transplant mg concentration could be at a higher risk for developing ifg.