Cushing's Syndrome Accompanied with Adrenal and Pancreatic Mass: A Case Report

Cushing's syndrome results from inappropriate excessive endogenous glucocorticoids secretion. it may be due to acth-producing pituitary adenoma, adrenocortical adenoma, iatrogen glu-cocorticoid use, or ectopic acth production. pa-tients, who remain untreated, have high morbid-ity and a significant mortality. we describe a very challenging case of cushing's syndrome due an adrenal adenoma on a pancreatic mass. material and methods: a 20-year-old woman presented with sign and symptoms of cushing syndrome. thorough basal and dynamic hor-monal assessment. in addition, the results of im-aging studies are presented. results: the source of acth secretion was adrenal adenoma, and hypercortisolism was con-trolled by adrenalectomy. a unique feature of this case is the fact that we observed an adrenal adenoma as a source of cushing syndrome and an incidental nonfunctional pancreatic nesidiob-lastosis. conclusion: the diagnosis of cushing's syn-drome may turn out to be sometimes a complex and time-consuming challenge in clinical endo-crinology.