Relationship between Plasma Antioxidant Status and Leptin in Controlled and Non-Controlled Type 2 Diabetic Non-Obese Women

It is an established fact that diabetes in duces oxidative stress; obesity is associated with type 2 diabetes mellitus (t2dm) and increased leptin levels. insulin has been suggested to be a regulator of in vivo leptin secretion, while hyperin- sulinaemia is a feature of t2dm. our study aimed at determining the relationship between plasma antioxidant status and leptin in controlled and non-controlled t2dm non obese women. materials and methods: sixty-five non- obese (bmi <26kg/m2) women with t2dm, 34 controlled (hbalc <6%) and 31 non-controlled (hbalc >8%), between the ages of 25-55 years were recruited for the study. plasma levels of leptin, a-tocopherol, retinol, total antioxidant status (tas), lipid peroxidation [malondialde- hyde(mda)], fasting plasma glucose(fpg), glycosylated haemoglobin (hbalc %), total cholesterol (tc), hdl-cholesterol, ldl-cholesterol and triglyceride (tg) were determined for all enrol- lees. results: mean±sd plasma a-tocopherol and tas for non-controlled t2dm subjects were significantly reduced compared to the controlled (p<0.01). however, the mean± sd plasma leptin and mda for the non-controlled t2dm subjects were significantly increased compared to the controlled (r=-0.23, p<0.05) and for the non-controlled (r=-0.51, p<0.01) t2dm group. likewise, there was an inverse correlation between leptin and a- tocopherol for the controlled (r=-0.25, p<0.05) and for the non-controlled (r=-0.49, p<0.01) t2dm groups. however, a direct correlation between leptin and mda was found for the controlled (r=0.21, p<0.05) and for the non- controlled (r=0.47, p<0.01) t2dm subjects. conclusion: our findings suggest that oxidative stress and leptin are associated with risk of t2dm and could be a target for insulin sensitization to prevent diabetes and its complications