Variation of Adiponectin Levels in Normal and Obese subjects: Possible Correlation with Lipid Profiles

Data available suggests that adiponec-tin, an adipocyte.derived peptide, is associated with adiposity and could ef- fect the regulation of glucose and lipid metabolism in humans. the aim of this study was to evaluate the association between serum adiponectin concentrations and anthro-pometric indices and lipid profiles among ira-nian women with different grades of obesity. materials and methods: in this analytical de-scriptive study of 157 non-diabetic women (33 normal weight, bmi< 25 kg/m2 and 124 over- weight and obese, bmi. 25kg/m2), serum adipo-nectin and leptin levels were measured using an enzyme-linked immunoassay. fasting glucose and lipid profile levels determined by the glucose oxidize and enzymatic methods, respectively. results: mean serum adiponectin concentra tionsignificantly decreased with obesity (p<0.05). although adiponectin showed a significant negative correlation with bmi (r=-0.321), it was cor- related with serum leptin (r=-0.139), glucose (r=0.259), ldl-c (r=-0.125), tgs (r=-0.210) levels, tsf (r=-0.145), whr (r=-0.159), and positively with serum hdl-c concentration (r=0.218) in all subjects (p<0.05). results of multiple regression analyses showed that adiponectin as a depen- dent variable had a significant correlation with bmi (s=-0.605, p=0.017), waist circumference (s=0.624,p=0.029),whr(s=-0.251, p=0.048), frame (s=0.260, p=0.018), tc/hdl-c ratio ( s=-0.1.309, p=0.040) and ldl/hdl ratio (ß=-1.343, p=0.007) and changes in waist size had a significant effect on serum adiponectin levels. conclusion: our results suggested that adiponectin had an inverse correlation with adiposity indices and unfavorable lipid profiles, and that variation of waist circumference mostly affected iranian women.